4. The use of a substance for non-medicinal purposes. liver damage, addiction and troubled behavior A. Drug Abuse B. Drug Tolerance C. Drug M 6. The condition of the body to adapt to the effects of larger amount of the substance to experience experienced when taking the smaller dosage. A.Drug Abuse B. Drug Tolerance C. Drug M 7. These are legal drugs that anybody can buy and try, such as marijuana and shabu. A. Gateway drugs B. Depressant drugs C. 7. Slow down a person's central nervous system (CNS) A. Gateway drugs B. Depressant drugs C.