Answer:
BLOOD AND CARDIOVASCULAR/CARDIAC TOXICITY
·BLOOD AND CARDIOVASCULAR/CARDIAC TOXICITY RESULTS FROM XENOBIOTICS ACTING DIRECTLY ON CELLS INCIRCULATING BLOOD,BONE MARROW,AND THE HEART.
EXMPLE OF BLOOD AND CARDIOVACULAR/CARDIAC TOXICITY ARE:
·HYPOXIA DUE TO CARBON MONOXIDE BINDING OF HEMOGLOBIN PREVENTING TRANSPORT OF OXYGEN.
·DECREASE IN CIRCULATING LEOKOCYTES DUE TO CHLORAMPHENICOL DAMAGE TO BONE MARROW CELLS
·LEUKEMIA DUE TO BENZENE DAMAGE OF BONE MARROW CELLS.
·ARTERIOCLEROSIS DUE TO CHOLESTEROL ACCUMULATION IN ARTERIES AND VEINS.
·DEATH OF NORMAL CELLS IN AND AROUND THE HEART AS A RESULTS OF EXPOSURE TO DRUGS USED TO TREAT CANCER
