Which of the following statement is TRUE to temperature as a factor of enzymatic reaction?

a.At the saturation point, the reaction will not speed up, no matter how much of this factor is added.
b.Increasing this factor can cause an enzyme to lose its shape (denature) and stop working.
c.Changing this factor outside the enzyme's optimum range will slow enzyme activity.
d. This factor at an optimum level, near neutral, causes enzymes to catalyze a reaction most rapidly.​