Answer:
In response to ADP, ATP or serotonin, endothelial cells can release arachidonic acid metabolites such as thromboxane A2, and, in response to thrombin, following the activation of protease-activated receptors (PAR), they release vWF, and the expression of tissue factor (TF) is up-regulated [1203,434] (Figure 2).
Monocytes originate in the bone marrow and travel through the blood stream to peripheral tissues. ... Classical monocytes, also called inflammatory monocytes, can infiltrate tissues, produce inflammatory cytokines, and differentiate into inflammatory macrophages.
